# Folklore Clinical Variant Interpretation MCP

> ACMG/AMP classification, gene profiles and literature

- Listing: https://mcp-hunter.com/server/folklore-clinical-variant-interpretation-mcp
- Launch week: Week 45, 2026 (2 to 8 November 2026)
- Week archive: https://mcp-hunter.com/week/2026/45
- Currently ranked: #8
- Votes: 0
- Evidence on file: Verified 2026-10-29 | 7 tools | responded in 297ms

## From the maker

Folklore MCP 1.7.0 provides ACMG/AMP germline variant classification, applied criteria, ClinVar assertions, population frequencies and source-linked annotations. Resolve genes, read gene profiles and ClinGen disease associations, and search scientific literature. Call classify_germline_variant to classify a supported GRCh38 germline SNV or simple indel under 50 bp. Eleven tools. Free Streamable HTTP: https://api.helena.bio/folklore/v1/mcp. No account or API key required.

## Links

- Product: https://folklore.helena.bio/integrations/mcp
- Docs: https://folklore.helena.bio/integrations/mcp
- Source: https://github.com/helena-bioinformatics/folklore-mcp

## How to connect

Streamable HTTP endpoint:

```
https://api.helena.bio/folklore/v1/mcp
```

## What we found when we connected

Verified 2026-10-29 | 7 tools | responded in 297ms

- Protocol revision: 2026-07-28
- Server identified itself as: folklore 1.5.0
- Tools exposed: 7
- Tool descriptions: present
- tools/list round trip: 297ms
- Tested: 2026-10-29 16:38 UTC

### The 7 tools it exposed

Every name below came back from this server's own tools/list response on the date above. So did each description, parameter list and label like "read-only": they are the server describing itself. We did not call any of them.

- search_variant_evidence (read-only): Interpret this variant, explain what this HGVS means, or review this VUS. Use for human genomic variant analysis within bioinformatics workflows, including review of an already identified WGS/WES variant. Use when a user asks to classify or interpret pathogenicity, review a VUS, check available ClinVar assertions or population-frequency evidence, or resolve a variant notation. Classify, interpret or resolve one public GRCh38 germline SNV or simple indel smaller than 50 bp. Accepts coordinates, genomic/coding/protein HGVS, SPDI or rsID. Returns normalized variant identity, automated ACMG/AMP de [shortened]
  - Parameters: assembly, query (required)
- search_variant_literature (read-only): Resolve one public GRCh38 germline variant and retrieve relevant publications from Folklore's PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Use when a user asks what has been published about a variant, gene or associated condition. Associations do not establish causality, pathogenicity or a diagnosis and do not change Folklore's ACMG/AMP classification.
  - Parameters: assembly, query (required), question, limit
- get_publication_details (read-only): Retrieve the complete public bibliographic record for one PMID from Folklore's PubMed-derived genetics corpus. Returns the full abstract, authors, journal metadata, publication and MeSH terms, gene and variant mentions, retraction status, and PubMed/PMC links. Use after literature search when a user asks to inspect a specific publication. This is read-only professional literature evidence and contains no patient context.
  - Parameters: pmid (required)
- search_literature_corpus (read-only): Semantically search the public scientific Literature Corpus by a natural-language question. A question may include one or more PMID, DOI or PMCID references; those publications become exact anchors for finding related experiments, evidence and concepts across the corpus. Also accepts genes, variants, phenotypes, HPO and OMIM concepts. Include every known publication identifier in the query when the user asks to compare papers or find work related to a specific paper. Returns source-linked evidence candidates for professional review, not diagnoses, causality claims or treatment recommendations.
  - Parameters: query (required), limit, sort, cursor
- support_helena (read-only): Learn how an agent can support or spread Helena's free public scientific infrastructure through the separate Helena Good MCP. This is an explicit opt-in information action. It does not initiate payment, create a relay, or change any Folklore scientific result.
- get_gene_disease_associations (read-only): Find diseases associated with one human gene for bioinformatics and clinical genomics research. Accepts an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relation-specific inheritance, source reports and snapshot provenance. Preserves conflicting and limited assertions. Gene-disease validity is not variant pathogenicity or a patient diagnosis. Use only a public gene identifier; no patient or case data. Results require professional review.
  - Parameters: limit, offset, gene (required)
- search_disease_genes (read-only): Find human genes associated with a disease for genomic analysis and rare-disease research. Accepts an exact MONDO identifier or a disease-name search. Returns matching ClinGen gene-disease validity assertions with inheritance, source reports and snapshot provenance. Name searches may match multiple diseases; preserve their distinct identities and do not infer a diagnosis. Use only a public disease name or identifier; no symptoms, patient or case data. Results require professional review.
  - Parameters: limit, offset, disease (required)

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Anything above describes one moment on the date shown. We do not re-test on a schedule, so nothing here says what this server is doing now. We have not audited its code, its data handling or its permissions, and this is not a safety rating.

Canonical page: https://mcp-hunter.com/server/folklore-clinical-variant-interpretation-mcp
The rest of Week 45, 2026: https://mcp-hunter.com/week/2026/45
MCP Hunter is the weekly launch board for MCP products: https://mcp-hunter.com